Ask An Expert: Hyperkeratosis and Pregnancy

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Ask An Expert: Hyperkeratosis and Pregnancy

Question:

I was diagnosed with hyperkeratosis after my last Pap smear. I'm now married and want a family. Will this decrease my chances of becoming pregnant?

Answer:

Hyperkeratosis is a thickening of the outer layer of cells on the surface of the cervix. This same process affecting the skin is called a callous. It is not a precancerous change, but instead forms in response to inflammation and trauma. For example, it may be seen in women with prolapse of the cervix, in which the uterine supports fail and the cervix drops out of the vagina and constantly rubs against the undergarments. It may also form after surgery on the cervix to treat precancerous changes.

Hyperkeratosis does not require treatment. However, some studies have shown a slight association with the cancer precursor, squamous intraepithelial lesion (SIL). Opinions vary regarding appropriate follow up. If other risk factors for SIL exist (smoking, multiple sexual partners, history of sexually transmitted diseases), testing for the human papillomavirus (HPV) may be recommended. In all cases, close follow up with a repeat Pap test in six to 12 months should be performed.

Hyperkeratosis alone has no impact on fertility or pregnancy risk.

Joan Bengtson, M.D., is assistant professor of obstetrics, gynecology and reproductive biology at Harvard Medical School and a member of the Department of Obstetrics, Gynecology & Reproduction at Brigham and Women's Hospital.

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Last updated:	January 24, 2007