Hemophilia inheritance pattern
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Hemophilia inheritance pattern
Source: Hillman RS, et al. (2005). Hemophilia and other intrinsic pathway defects. In RS Hillman et al., eds., Hematology in Clinical Practice, 4th ed., chap. 32, pp. 368–379. New York: McGraw-Hill.
- If the father has hemophilia and the mother is a carrier, sons will have a 50% chance of having hemophilia. Daughters will have a 50% chance of having hemophilia and a 50% chance of being a carrier. It is very rare for both parents to have these defective genes.
- If the father does not have hemophilia and the mother is a carrier, sons will have a 50% chance of having hemophilia. Daughters will have a 50% chance of being carriers.
- If the father has hemophilia and the mother has normal blood, all sons will be normal and all daughters will be carriers.
- About 33% of hemophilia occurs spontaneously when a normal chromosome changes (mutates).
Credits
| Primary Medical Reviewer | Anne C. Poinier, MD - Internal Medicine |
| Specialist Medical Reviewer | Brian Leber, MDCM, FRCPC - Hematology |
| Last Updated | August 20, 2007 |
| Last updated: | August 20, 2007 |
|---|---|
| Reviewed By: | Anne C. Poinier, MD - Internal Medicine, Brian Leber, MDCM, FRCPC - Hematology |
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