Antisperm Antibody Test
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Test Overview
An antisperm antibody test looks for special proteins (antibodies) that fight against a man's sperm in blood, vaginal fluids, or semen. The test uses a sample of sperm and adds a substance that binds only to affected sperm.
Semen can cause an immune system response in either the man's or woman's body. The antibodies can damage or kill sperm. If a high number of sperm antibodies come into contact with a man's sperm, it may be hard for the sperm to fertilize an egg. The couple has a hard time becoming pregnant. This is called immunologic infertility.
A man can make sperm antibodies when his sperm come into contact with his immune system. This can happen when the testicles are injured or after surgeries (such as a biopsy or vasectomy) or after a prostate gland infection. The testicles normally keep the sperm away from the rest of the body and the immune system.
A woman can have an allergic reaction to her partner's semen and make sperm antibodies. This kind of immune response is not fully understood but may affect fertility. This is a rare cause of infertility.
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| Last updated: | March 21, 2008 |
|---|---|
| Author: | Sandy Jocoy, RN |
| Reviewed By: | Sarah Marshall, MD - Family Medicine, Kirtly Jones, MD - Obstetrics and Gynecology |
| Editors: | Kathleen M. Ariss, MS, Pat Truman, MATC |
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