Growing New Brain Cells - How Memory Changes With Age: Improving Memory Understanding Age Related Memory Loss
Growing new brain cells
Another surprise in our concept of brain aging concerns the growth of new neurons. In the early 1970s, researchers found that adult rats and guinea pigs did in fact grow new neurons. The same proved true for cats, chickadees, tree shrews, and marmoset monkeys. But most scientists clung to the assumption that adult humans were different from these animals until 1998, when they found compelling evidence to the contrary.
The evidence came from a study of five people who had died of cancer. Before their deaths, their brains had been injected with a chemical that helped doctors count the number of new cells. The intent was to count the number of new cancer cells. But the chemical also revealed the number of new healthy cells. Sure enough, all five patients had recently sprouted new healthy neurons. And these neurons were in the hippocampus.
This finding was nothing short of revolutionary. It transformed the way neuroscientists think about the aging brain and memory. They now believe that, in most cases, even when a person is very old, his or her brain is capable of producing new neurons in order to maintain established connections — pathways that encode long-term memories and enable the person to acquire new memories. And if the brain is able to generate new neurons, there's hope that one day it may be possible to offset the damage and severe memory loss brought on by degenerative brain disorders such as Alzheimer's disease.
Meanwhile, there are still many unanswered questions about the aging brain. For one thing, scientists don't know how many new neurons a person gains each day, how long the cells live, or what substances may maintain their life. We know that high levels of stress hormones released during weeks or months of extreme stress interfere with the growth and survival of new neurons. But the influence of sex hormones on neuronal development and longevity has turned out to be much more complex than originally thought. For example, early studies of estrogen suggested it might protect neurons, at least in premenopausal women. On the other hand, research shows that hormone therapy — a combination of estrogen and progestin (a synthetic hormone) taken by women to treat symptoms of menopause — doesn't guard against age-related memory loss in postmenopausal women, as once had been assumed. In fact, in one major study, it actually increased the risk of dementia (see "Estrogen therapy and memory").
Are recovered memories real?Recovered memories are vivid, emotionally powerful recollections of events or occurrences from the distant past that a person has not thought of in years. These memories are frequently recovered in the course of psychotherapy. The use of such memories — in particular, as evidence of past child abuse, incest, or other traumatic events — has engendered considerable controversy. Critics of the concept of recovered memory point out that memory is not a literal register of experience. What we remember — and how we remember it — is influenced by our personalities, as well as our beliefs, hopes, and needs. New experiences interact with old memories and cause them to distort or decay, and we may fill in the gaps, merge the memories of several events, or confuse what we had imagined or heard about with what we actually witnessed or experienced. Critics charge that recovered memories often reflect the power of suggestion during psychotherapy sessions and that the therapist, an authority figure, plays the key role in encouraging false memories to emerge. Similarly, when the memory of distant events is a vital aspect of a criminal investigation, police, social workers, and other officials can intentionally or unintentionally influence what a person remembers. Champions of the recovered memory concept, on the other hand, insist that the more unusual and disturbing the memory, the less likely it is to be false. If anything, they say, people tend to doubt recovered memories of child abuse longer than they should. Advocates say that most recovered memories are spontaneous and are not generated as the result of a therapist's intervention, although they may be revealed in that context because the therapist creates a safe environment in which to disclose them. Both sides in this dispute have tried to support their positions with evidence from neurology and cognitive neuroscience, including animal experiments, brain scans, neuropsychological tests, and the examination of brain-damaged patients. The majority of mental health professionals take a position between the two extremes. Although there is no established consensus, we know that memories can contain varying elements of truth, partial truth, or distortion, and individuals have different capacities for remembering and forgetting. A true memory (recovered or persistent) cannot be distinguished from a false one on the basis of internal evidence alone. Instead, people must tolerate some uncertainty. More research is needed on the prevalence of false memories and delayed recall. As research clarifies the subtle nuances of how normal memory works, scientists will gain a better understanding of the interplay between knowledge and emotion in the recollection of traumatic experiences and may reach a consensus on the usefulness and reliability of recovered memories. |
| Last updated: | January 23, 2007 |
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Medical content reviewed by the Faculty of the Harvard Medical School. Harvard Health Publications, Copyright © 2007 by President and Fellows of Harvard College. All rights reserved. Used with permission of StayWell.
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