Smallpox: Exams And Tests


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Exams and Tests


A suspected first case of smallpox is considered an international health emergency. Specialized laboratory testing is necessary to confirm a suspected smallpox infection.

  • Specially trained and vaccinated health professionals take fluid samples from the person's mouth or from the suspected smallpox lesions.
  • The sealed samples are shipped to the Centers for Disease Control and Prevention (CDC) or another designated laboratory that is equipped to handle the variola virus.

In the laboratory, variola virus can be quickly identified using a combination of:

If a smallpox (variola) outbreak is already documented, a physical exam and history of symptoms and exposure may be sufficient for your doctor to diagnose smallpox.



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Last updated: January 31, 2007
Author: Debby Golonka, MPH
Reviewed By: William M. Green, MD - Emergency Medicine, Christine Hahn, MD - Epidemiology
Editors: Susan Van Houten, RN, BSN, MBA, Pat Truman, MATC

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