Sibutramine (oral): What Other Drugs Will Affect Sibutramine

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What other drugs will affect sibutramine?

Do not take sibutramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), tranylcypromine (Parnate), or phenelzine (Nardil) in the last 14 days. A dangerous drug interaction may occur.

Before taking this medication, tell your doctor if you are taking

• lithium (Lithobid, Eskalith, Lithonate, others);
• almotriptan (Axert), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), eletriptan (Relpax), frovatriptan (Frova), or zolmitriptan (Zomig);
• venlafaxine (Effexor), duloxetine (Cymbalta), nefazodone (Serzone), mirtazapine (Remeron), or thioridazine (Mellaril);
• citalopram (Celexa), fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), or fluvoxamine (Luvox);
• amitriptyline (Elavil, Endep), amoxapine (Asendin), clomipramine (Anafranil), desipramine (Norpramin), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), or trimipramine (Surmontil);
• dihydroergotamine (D.H.E.);
• an oral anticoagulant or drugs that may increase bleeding such as warfarin (Coumadin), ticlopidine (Ticlid), clopidogrel (Plavix), pentoxifylline (Trental) , aspirin, and others;
• dextromethorphan (in many cough medicines);
• meperidine (Demerol);
• fentanyl (Duragesic); or
• pentazocine (Talacen, Talwin).

Sibutramine may interact with the medicines listed above and cause a condition called Serotonin Syndrome. This syndrome requires immediate medical attention and may include one or more of the following symptoms: anxiety, restlessness, loss of consciousness, confusion, weakness, tremor, poor coordination, fever, shivering, sweating, vomiting, a fast heartbeat, and others. Do not take any other prescription or over-the-counter medicines without first talking to your doctor, especially weight-loss products, tryptophan (L-tryptophan, 5-HTP), decongestants, antidepressants, cough suppressants, lithium (Eskalith, Lithobid, Lithonate, others), or migraine medicines.

Drugs other than those listed here may also interact with sibutramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines including vitamins, minerals, and herbal products.

Last updated:	January 14, 2005