Nefazodone: What Should I Discuss With My Healthcare Provider Before Taking Nefazodone

Content provided by Cerner Multum, Inc.

What should I discuss with my healthcare provider before taking nefazodone?

You should not take this medication if you are allergic to nefazodone or trazodone (Desyrel), or if you have ever had liver problems caused by taking nefazodone.

Do not take nefazodone if you are using any of the following drugs:

• carbamazepine (Tegretol);
• cisapride (Propulsid);
• pimozide (Orap);
• an MAO inhibitor such as isocarboxazid (Marplan), tranylcypromine (Parnate), phenelzine (Nardil), rasagiline (Azilect), or selegiline (Eldepryl, Emsam); or
• (these drugs are no longer available in the U.S.) astemizole (Hismanal) or terfenadine (Seldane).

Serious and sometimes fatal reactions can occur when these medicines are taken with nefazodone. You must wait at least 14 days after stopping an MAO inhibitor before you can take nefazodone. You must wait 7 days after stopping nefazodone before you can take an MAOI.

Before taking nefazodone, tell your doctor if you are allergic to any drugs, or if you have:

• liver disease (especially cirrhosis);
• heart disease or recent heart attack;
• bipolar disorder (manic depression);
• epilepsy or other seizure disorder; or
• a history of suicidal thoughts or actions.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take nefazodone.

You may have thoughts about suicide while taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether nefazodone passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Last updated:	March 05, 2008