Methyldopa for chronic hypertension during pregnancy


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Generic Name
methyldopa

Methyldopa reduces high blood pressure (hypertension). It is given as tablets or liquid (orally) or through a vein (intravenously, or IV).


How It Works


Methyldopa affects the nerves that relax the walls of blood vessels, causing the blood vessels to widen (dilate) and thus reducing blood pressure.


Why It Is Used


Methyldopa is used to help control blood pressure in chronic hypertension during pregnancy. Other medicines may be added for blood pressure control, if needed.

Methyldopa is not used in women who have liver or kidney disease.


How Well It Works


Methyldopa is usually effective for the control of chronic hypertension during pregnancy.1


Side Effects


The side effects of methyldopa are usually mild and may include:

  • Sleepiness.
  • Dry mouth.
  • Weakness when treatment first begins.
  • Low blood pressure.
  • Swelling of the feet and legs and weight gain caused by fluid retention (edema).
  • Slow heart rate (bradycardia).
  • Nausea and vomiting.
  • Constipation.
  • Diarrhea.
  • Headache, dizziness, or lightheadedness.
  • Blood abnormalities (rare).

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)


What To Think About


Methyldopa is generally considered safe for use during pregnancy.

Methyldopa is most often used in its oral form for the treatment of high blood pressure during pregnancy.

Methyldopa does not begin lowering blood pressure until 4 to 6 hours after it is taken. So it is not a good choice when blood pressure needs to be lowered quickly.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.


References


Citations

  1. Magee LA (2001). Antihypertensives. Best Practice and Research: Clinical Obstetrics and Gynaecology, 15(6): 827–845.


Credits


Author Sandy Jocoy, RN
Editor Kathleen M. Ariss, MS
Associate Editor Pat Truman, MATC
Primary Medical Reviewer Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer Deborah A. Penava, BA, MD, FRCSC, MPH - Obstetrics and Gynecology
Last Updated November 14, 2008


Healthwise Logo
Last updated: November 14, 2008
Author: Sandy Jocoy, RN
Reviewed By: Sarah Marshall, MD - Family Medicine, Deborah A. Penava, BA, MD, FRCSC, MPH - Obstetrics and Gynecology
Editors: Kathleen M. Ariss, MS, Pat Truman, MATC

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