Hydroxyzine: What Other Drugs Will Affect Hydroxyzine

Content provided by Cerner Multum, Inc.

What other drugs will affect hydroxyzine?

Many drugs may increase the effects of hydroxyzine and lead to heavy sedation. Before taking this medication, tell your doctor if you are taking any of the following drugs:

• other antihistamines, such as brompheniramine (Dimetane, Bromphen, others), chlorpheniramine (Chlor-Trimeton, Teldrin, others), azatadine (Optimine), clemastine (Tavist), and many others;
• narcotics (pain killers) such as meperidine (Demerol), morphine (MS Contin, MSIR, others), propoxyphene (Darvon, Darvocet), hydrocodone (Lorcet, Vicodin), oxycodone (Percocet, Percodan), fentanyl (Duragesic), and codeine (Fiorinal, Fioricet, Tylenol #3, others);
• sedatives such as phenobarbital (Solfoton, Luminal), amobarbital (Amytal), and secobarbital (Seconal);
• phenothiazines such as chlorpromazine (Thorazine), fluphenazine (Prolixin), mesoridazine (Serentil), perphenazine (Trilafon), prochlorperazine (Compazine), thioridazine (Mellaril), and trifluoperazine (Stelazine); or
• antidepressants such as amitriptyline (Elavil), doxepin (Sinequan), imipramine (Tofranil), nortriptyline (Pamelor), fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft), phenelzine (Nardil), and tranylcypromine (Parnate).

Drugs other than those listed here may also interact with hydroxyzine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Last updated:	February 13, 2004