Hydrochlorothiazide And Spironolactone: What Other Drugs Will Affect Hydrochlorothiazide And Spironolactone


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What other drugs will affect hydrochlorothiazide and spironolactone?


Before taking this medication, tell your doctor if you are using any of the following drugs:

  • lithium;
  • digoxin (Lanoxin);
  • steroids (prednisone and others);
  • a blood thinner such as warfarin (Coumadin);
  • insulin or diabetes medicine taken by mouth;
  • an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or
  • indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.

This list is not complete and there may be other drugs that can interact with hydrochlorothiazide and spironolactone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.



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Last updated: March 31, 2008

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