Gonadotropin-releasing Hormone Analogue (GnRH-a) Therapy

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gonadotropin-releasing hormone analogue (GnRH-a)

Brand Name	Generic Name
Zoladex	goserelin acetate

Brand Name	Generic Name
Lupron Depot	leuprolide acetate

Brand Name	Generic Name
Synarel	nafarelin acetate

Leuprolide is injected into a muscle (intramuscularly) once a month. It is also available in a dose that lasts for 3 months.
Nafarelin is sprayed into the nose (intranasally) twice a day.
Goserelin (3.6 mg pellet) is injected under the skin of the abdomen (subcutaneously) once every 28 days. The pellet is gradually absorbed by the body.

Gonadotropin-releasing hormone analogue (GnRH-a) therapy is approved for the treatment of endometriosis and uterine fibroids. A GnRH-a is rarely used for dysfunctional uterine bleeding.

GnRH-a therapy is usually taken for only 3 to 6 months to avoid long-term side effects.

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Last updated:	August 16, 2007
Author:	Kathe Gallagher, MSW
Reviewed By:	Kathleen Romito, MD - Family Medicine, Kirtly Jones, MD - Obstetrics and Gynecology
Editors:	Kathleen M. Ariss, MS, Pat Truman, MATC

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