Glyburide And Metformin: What Should I Discuss With My Healthcare Provider Before Taking Glyburide And Metformin

Content provided by Cerner Multum, Inc.

What should I discuss with my healthcare provider before taking glyburide and metformin?

Some people have developed a life-threatening condition called lactic acidosis while taking glyburide and metformin. Get emergency medical help if you have any of these symptoms of lactic acidosis: weakness, increasing sleepiness, slow heart rate, cold feeling, muscle pain, shortness of breath, stomach pain, feeling light-headed, and fainting.

You may be more likely to develop lactic acidosis if you have congestive heart failure.

Do not use glyburide and metformin if you have congestive heart failure or kidney disease, or if you are in a state of diabetic ketoacidosis (call your doctor for treatment with insulin).

Before taking this medication, tell your doctor if you have:

• heart disease;
• liver disease; or
• a history of heart attack or stroke.

If you have any of these conditions, you may not be able to use glyburide and metformin, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether glyburide and metformin passes into breast milk or if it could harm a nursing baby. Do not take glyburide and metformin without first talking to your doctor if you are breast-feeding a baby.

Older adults may have a higher risk of developing lactic acidosis. Talk with your doctor about your individual risk.

Last updated:	January 14, 2007