Fulvestrant
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Examples
| Brand Name | Generic Name |
| Faslodex | fulvestrant |
Fulvestrant is available as an intramuscular (IM) injection.
How It Works
Fulvestrant is called an antiestrogen medicine. This means that it blocks the effect of estrogen in the body. It is only used for postmenopausal women who have been diagnosed with estrogen receptor-positive (ER+) breast cancer.1
Why It Is Used
Fulvestrant is used to treat estrogen receptor-positive (ER+) metastatic breast cancer in postmenopausal women when other hormonal therapies, such as tamoxifen, have stopped working.
How Well It Works
Fulvestrant is as effective as aromatase inhibitors, such as anastrozole (Arimidex), in the treatment of women with metastatic breast cancer when other hormonal therapies, such as tamoxifen, have stopped working.2 It only works for postmenopausal women who have been diagnosed with estrogen receptor-positive (ER+) breast cancer.
Side Effects
Most women do not have problems with side effects while taking fulvestrant. When side effects happen, they are generally mild and may include:
- Nausea or vomiting.
- Constipation or diarrhea.
- Abdominal pain.
- Headache.
- Back pain.
- Hot flashes.
- Sore throat.
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Fulvestrant should be given only under the supervision of a medical oncologist. It is approved for use after menopause.
Fulvestrant is not effective before menopause. Estrogen production during menstruation is not affected by these medicines.
Further study is needed to determine how long to use fulvestrant. It hasn't been studied long enough to answer this question.
Do not take this medicine if you are or may be pregnant. Do not breast-feed while you are taking this medicine.
Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.
References
Citations
National Cancer Institute (2004). Fulvestrant: New treatment option for advanced breast cancer. Available online: http://www.nci.nih.gov/clinicaltrials/results/fulvestrant0802.
Abramowicz M (2005). Drugs for breast cancer. Treatment Guidelines From the Medical Letter, 3(29): 1–6.
Credits
| Author | Kathe Gallagher, MSW |
| Editor | Kathleen M. Ariss, MS |
| Editor | Cynthia Tank |
| Associate Editor | Pat Truman, MATC |
| Primary Medical Reviewer | Joy Melnikow, MD, MPH - Family Medicine |
| Specialist Medical Reviewer | Douglas A. Stewart, MD - Medical Oncology |
| Last Updated | August 31, 2007 |
| Last updated: | August 31, 2007 |
|---|---|
| Author: | Kathe Gallagher, MSW |
| Reviewed By: | Joy Melnikow, MD, MPH - Family Medicine, Douglas A. Stewart, MD - Medical Oncology |
| Editors: | Cynthia Tank, Pat Truman, MATC |
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