Diphenhydramine: What Other Drugs Will Affect Diphenhydramine
Content provided by Cerner Multum, Inc.
What other drugs will affect diphenhydramine?
 | Do not take diphenhydramine if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. A very dangerous drug interaction could occur, leading to serious side effects. |
Talk to your pharmacist before taking other over-the-counter cough, cold, allergy, or insomnia medications. These products may contain medicines similar to diphenhydramine, which could lead to an antihistamine overdose.
Before taking this medication, tell your doctor if you are taking any of the following medicines:
- anxiety or sleep medicines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), temazepam (Restoril), or triazolam (Halcion);
- medications for depression such as amitriptyline (Elavil), doxepin (Sinequan), nortriptyline (Pamelor), fluoxetine (Prozac), sertraline (Zoloft), or paroxetine (Paxil); or
- any other medications that make you feel drowsy, sleepy, or relaxed.
Drugs other than those listed here may also interact with diphenhydramine. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines, including vitamins, minerals, and herbal products.
| Last updated: | February 13, 2004 |
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© 2007, Cerner Multum, INC. Version: 5.02.
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