Cisapride (oral): What Other Drugs Will Affect Cisapride

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What other drugs will affect cisapride?

Do not take cisapride with any of the following drugs: antibiotics such as clarithromycin (Biaxin), erythromycin (Ery-Tab, E.E.S., E-Mycin, others), troleandomycin (TAO), and sparfloxacin (Zagam); antidepressants such as amitriptyline (Elavil), maprotiline (Ludiomil), and nefazodone (Serzone); antifungal medications such as fluconazole (Diflucan), itraconazole (Sporanox), and ketoconazole (Nizoral); phenothiazines such as prochlorperazine (Compazine, others) and promethazine (Phenergan, others); antihistamines such as astemizole (Hismanal); blood pressure medications such as bepridil (Vascor); heart medications such as procainamide (Procan SR, Procanbid, Pronestyl) and quinidine (Quinidex, Quinaglute); and HIV medications such as indinavir (Crixivan) and ritonavir (Norvir). Taken with any of these drugs, cisapride may cause irregular heartbeats that could lead to death. This is not a complete list of drugs that may interact with cisapride and cause heart problems. Talk to your doctor or pharmacist before taking any other medications.

The effects of cisapride may be decreased by drugs such as clidinium (Quarzan), dicyclomine (Bentyl), hyoscyamine (Levsin, Cystospaz, Anaspaz), belladonna (Donnatal), and propantheline (Pro-Banthine).

Cimetidine (Tagamet, Tagamet HB) may increase the level of cisapride in your body. Talk to your doctor before taking cimetidine during treatment with cisapride.

Warfarin (Coumadin) may have increased effects during treatment with cisapride. This could lead to bleeding. Your doctor may need to make adjustments to your warfarin dosage.

Use other medications cautiously during treatment with cisapride to avoid harming yourself or others. Excessive drowsiness may result if benzodiazepines such as alprazolam (Xanax), diazepam (Valium), chlordiazepoxide (Librium), and temazepam (Restoril) are taken during cisapride therapy.

Drugs other than those listed here may also interact with cisapride. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Last updated:	July 29, 2004