Triplo X Syndrome

Content provided by National Organization for Rare Disorders

Important

It is possible that the main title of the report Triplo X Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• Triple X Syndrome
• 47,XXX Syndrome
• 47,XXX Karyotype
• 47,XXX Chromosome Constitution
• Trisomy X

Disorder Subdivisions

• None

General Discussion

Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.



However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.



Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.

.

Resources

March of Dimes Birth Defects Foundation

1275 Mamaroneck Avenue

White Plains, NY 10605

Tel: (914)428-7100

Fax: (914)997-4763

Tel: (888)663-4637

Email: Askus@marchofdimes.com

Internet: http://www.marchofdimes.com



National Dissemination Center for Children with Disabilities

P.O. Box 1492

Washington, D.C. 20013

USA

Tel: 2028848200

Fax: 2028848441

Tel: 8006950285

TDD: 8006950285

Email: nichcy@aed.org

Internet: http://www.nichcy.org



National Center for Learning Disabilities

381 Park Avenue South

#1401

New York, NY 10016

Tel: (212)545-7510

Fax: (212)545-9665

Tel: (888)575-7373

Email: help@ncld.org

Internet: http://www.ld.org



Learning Disabilities Association of America

4156 Library Road

Pittsburgh, PA 15234-1349

Tel: (412)341-1515

Fax: (412)344-0224

Tel: (888)300-6710

Email: info@ldaamerica.org

Internet: http://www.ldaamerica.org



International Dyslexia Association

Chester Building

Suite 382

8600 LaSalle Road

Baltimore, MD 21286-2044

USA

Tel: 4102960232

Fax: 4103215069

Tel: 8002223123

Email: info@interdys.org

Internet: http://www.interdys.org



UNIQUE - Rare Chromosome Disorder Support Group

P.O. Box 2189

Caterham

Surrey, Intl CR3 5GN

United Kingdom

Tel: 44 0 1883 330766

Fax: 44 0 1883 330766

Email: info@rarechromo.org

Internet: http://www.rarechromo.org



Klinefelter Syndrome & Associates (KS&A)

11 Keats Court

Coto de Caza, CA 92679

Tel: (888)999-9428

Fax: (949)858-3443

Tel: (888)999-9428

Email: khenry@genetic.org

Internet: http://www.genetic.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  5/8/2008

Copyright  1995, 1996, 1997, 1998, 2001 National Organization for Rare Disorders, Inc.

Last updated:	May 08, 2008