Triplo X Syndrome
Content provided by National Organization for Rare Disorders
Important
It is possible that the main title of the report Triplo X Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms
- Triple X Syndrome
- 47,XXX Syndrome
- 47,XXX Karyotype
- 47,XXX Chromosome Constitution
- Trisomy X
Disorder Subdivisions
- None
General Discussion
Triplo X Syndrome is a chromosomal abnormality that affects females. Females normally have two X chromosomes; however, those with Triplo X Syndrome carry three X chromosomes (trisomy X) in the nuclei of body cells. No specific pattern of symptoms and malformations (phenotype) has been found to be associated with this abnormal chromosomal make-up (i.e., 47,XXX karyotype). Many affected females appear to have no or very few associated symptoms, while others may have various abnormalities.
However, investigators indicate that Triplo X Syndrome is a relatively common cause of learning difficulties, particularly language-based disabilities (e.g., dyslexia), in females. Evidence suggests that affected females typically have normal intelligence with IQs that tend to be lower than that of their brothers and sisters (siblings). Mental retardation rarely occurs. Infants and children with Triplo X Syndrome may tend to have delayed acquisition of certain motor skills and delayed language and speech development.
Affected females often are of tall stature. According to researchers, although sexual development and fertility are usually normal, some may have delayed puberty and/or fertility problems. In addition, in some cases, certain physical abnormalities have been reported, such as a relatively small head, vertical skin folds that may cover the eyes' inner corners (epicanthal folds), and/or other findings. Triplo X Syndrome results from errors during the division of reproductive cells in one of the parents.
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Resources
March of Dimes Birth Defects Foundation
1275 Mamaroneck Avenue
White Plains, NY 10605
Tel: (914)428-7100
Fax: (914)997-4763
Tel: (888)663-4637
Email: Askus@marchofdimes.com
Internet: http://www.marchofdimes.com
National Dissemination Center for Children with Disabilities
P.O. Box 1492
Washington, D.C. 20013
USA
Tel: 2028848200
Fax: 2028848441
Tel: 8006950285
TDD: 8006950285
Email: nichcy@aed.org
Internet: http://www.nichcy.org
National Center for Learning Disabilities
381 Park Avenue South
#1401
New York, NY 10016
Tel: (212)545-7510
Fax: (212)545-9665
Tel: (888)575-7373
Email: help@ncld.org
Internet: http://www.ld.org
Learning Disabilities Association of America
4156 Library Road
Pittsburgh, PA 15234-1349
Tel: (412)341-1515
Fax: (412)344-0224
Tel: (888)300-6710
Email: info@ldaamerica.org
Internet: http://www.ldaamerica.org
International Dyslexia Association
Chester Building
Suite 382
8600 LaSalle Road
Baltimore, MD 21286-2044
USA
Tel: 4102960232
Fax: 4103215069
Tel: 8002223123
Email: info@interdys.org
Internet: http://www.interdys.org
UNIQUE - Rare Chromosome Disorder Support Group
P.O. Box 2189
Caterham
Surrey, Intl CR3 5GN
United Kingdom
Tel: 44 0 1883 330766
Fax: 44 0 1883 330766
Email: info@rarechromo.org
Internet: http://www.rarechromo.org
Klinefelter Syndrome & Associates (KS&A)
11 Keats Court
Coto de Caza, CA 92679
Tel: (888)999-9428
Fax: (949)858-3443
Tel: (888)999-9428
Email: khenry@genetic.org
Internet: http://www.genetic.org
For a Complete Report
This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html
The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.
It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.
This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.
For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org
Last Updated: 5/8/2001
Copyright 1995, 1996, 1997, 1998, 2001 National Organization for Rare Disorders, Inc.
| Last updated: | May 08, 2001 |
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Copyright 1989, 1995, 1996, 1997, 2003 National Organization for Rare Disorders, Inc.
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