Rosai-Dorfman Disease

Content provided by National Organization for Rare Disorders

Important

It is possible that the main title of the report Rosai-Dorfman Disease is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• RDD
• Sinus Histiocytosis with Massive Lymphadenopathy
• SHML

Disorder Subdivisions

• None

General Discussion

Rosai-Dorfman disease is a rare disorder characterized by over-production (proliferation) and accumulation of a specific type of white blood cell (histiocyte) in the lymph nodes of the body (lymphadenopathy), most often those of the neck (cervical lymphadenopathy). In some cases, abnormal accumulation of histiocytes may occur in other areas of the body besides the lymph nodes (extranodal). These areas include the skin, central nervous system, kidney, and digestive tract. The symptoms and physical findings associated with Rosai-Dorfman disease vary depending upon the specific areas of the body that are affected. The exact cause of Rosai-Dorfman disease is unknown.

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Resources

Histiocytosis Association of America

332 North Broadway

Pitman, NJ 08071

Tel: (856)589-6606

Fax: (856)589-6614

Tel: (800)548-2758

Email: association@histio.org

Internet: http://www.histio.org



NIH/National Heart, Lung and Blood Institute

31 Center Drive MSC 2480

Building 31A Rm 4A16

Bethesda, MD 20892-2480

Tel: (301)592-8573

Fax: (240)629-3246

Email: nhlbiinfo@rover.nhlbi.nih.gov

Internet: http://www.nhlbi.nih.gov/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  8/17/2007

Copyright  2002, 2003, 2004, 2007 National Organization for Rare Disorders, Inc.

Last updated:	August 17, 2007