Mikulicz Syndrome

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Important

It is possible that the main title of the report Mikulicz Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• Dacryosialoadenopathia
• Dacryosialoadenopathy
• Mikulicz Syndrome
• Mikulicz-Radecki Syndrome
• Mikulicz-Sjogren Syndrome
• von Mikulicz Syndrome

Disorder Subdivisions

• None

General Discussion

Mikulicz syndrome is a chronic condition characterized by the abnormal enlargement of glands in the head and neck, including those near the ears (parotids) and those around the eyes (lacrimal) and mouth (salivary). The tonsils and other glands in the soft tissue of the face and neck may also be involved. Although the disorder is almost always described as benign, it always occurs in association with another underlying disorder such as tuberculosis, leukemia, syphilis, Hodgkin’s disease, lymphosarcoma, Sjogren syndrome, or lupus (SLE). People who have Mikulicz syndrome are at heightened risk for developing lymphomas.



Some people with Mikulicz syndrome may experience recurring fevers. The fever may be accompanied by dry eyes, diminished tear production (lacrimation), and inflammation of various parts of the eyes (uveitis). Lacrimal gland enlargement, parotid gland enlargement, dry mouth and dry eyes are the classic signs.



The exact cause of Mikulicz syndrome is not known. Some scientists believe that Mikulicz syndrome should be considered a form of Sjogren syndrome.

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Resources

American Autoimmune Related Diseases Association, Inc.

22100 Gratiot Avenue

Eastpointe, MI 48021-2227

Tel: (586)776-3900

Fax: (586)776-3903

Tel: (800)598-4668

Email: aarda@aarda.org

Internet: http://www.aarda.org/



Sjogren's Syndrome Foundation, Inc.

8120 Woodmont Ave

Suite 530

Bethesda, MD 20814

Tel: (301)718-0300

Fax: (301)718-0322

Tel: (800)475-6473

Internet: http://www.sjogrens.org



NIH/National Oral Health Information Clearinghouse

1 NOHIC Way

Bethesda, MD 20892-3500

USA

Tel: 3014027364

Fax: 3019078830

TDD: 3016567581

Email: nohic@nidcr.nih.gov

Internet: http://www.nohic.nidcr.nih.gov



AutoImmunity Community



Tel: (919)-55-2-9057

Email: bandrews@autoimmunitycommunity.org

Internet: http://autoimmunitycommunity.org

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  4/18/2008

Copyright  1986, 1994, 2003 National Organization for Rare Disorders, Inc.

Last updated:	April 18, 2008