Malignant Hyperthermia

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Important

It is possible that the main title of the report Malignant Hyperthermia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• Hyperthermia of Anesthesia
• Malignant Hyperpyrexia

Disorder Subdivisions

• None

General Discussion

Malignant hyperthermia (MH) is an autosomal dominant genetic disorder in which affected individuals are susceptible to adverse reactions to certain anesthetic drugs. The drugs that trigger malignant hyperthermia are the volatile inhalation gases including sevoflurane, desflurane, isoflurane, halothane, enflurane, methoxyflurane and depolarizing muscle relaxants such a succinylcholine. The characteristics of a malignant hyperthermia episode are variable and include muscle rigidity, high blood pressure (hypertension) increased levels of carbon monoxide in blood or exhaled gas, rapid irregular heart rate, rapid deep breathing, blue skin, acidity of the blood and muscle damage. Body temperature can rise rapidly (hyperthermia), but sometimes only occurs late in an episode. When an episode is not recognized and treated, internal bleeding, brain damage, skeletal muscle degeneration (rhabdomyolysis), and kidney and heart failure can result.

Resources

Malignant Hyperthermia Association of the United States (MHAUS)

11 East State Street

PO Box 1069

Sherburne, NY 13460-1069

USA

Tel: 6076747901

Fax: 6076747910

Email: info@mhaus.org

Internet: http://www.mhaus.org



North American Malignant Hyperthermia Registry of MHAUS

Children's Hospital of Pittsburgh

Room #7446

3705 Fifth Ave at DeSoto St

Pittsburgh, PA 15213-2583

USA

Tel: 4126926390

Fax: 4126928658

Tel: 8882747899

Email: bwb+@pitt.edu

Internet: http://www.mhreg.org



Malignant Hyperthermia Hotline

MHAUS Hotline (available 24 hours a day)

If outside the U.S., call 0011 315 464 7079

95382

United States

Fax: (607) 674-7910

Tel: 8006449737

Internet: http://www.mhaus.org



NIH/National Institute of General Medical Sciences

45 Center Dr MSC 6200

Bethesda, MD 20892-6200

Tel: (301)496-7301

Fax: (301)402-0224



Malignant Hyperthermia Investigation Unit

Toronto General Hospital

200 Elizabeth Street

CCRW-2, Room ES3-403A

Toronto

Ontario, Intl M5G 2C4

Canada

Tel: (416)340-3128

Fax: (416)340-4960

Email: info@mhacanada.org

Internet: http://www.mhacanada.org



MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network

150 Custer Court

Green Bay, WI 54301-1243

USA

Tel: 9203365333

Fax: 9203390995

Tel: 8773365333

Email: mums@netnet.net

Internet: http://www.netnet.net/mums/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  5/23/2008

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Last updated:	May 23, 2008