Liquid-based collection methods for cervical cell evaluation


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Liquid-based collection methods for cervical cell evaluation


Liquid-based methods for collecting cervical cells and preparing them for laboratory evaluation are now available.

A sample of cervical cells is collected during a Pap test, and the cells are then rinsed in a liquid vial instead of being smeared on slides. The vials are taken to the laboratory, and a thin layer of the specimen is put on slides for microscopic examination. Only a small portion of the sample is used for the slide, so the remainder of the cell sample can be used for any additional testing, such as a human papillomavirus (HPV) test.

Some studies show that this method may be more sensitive in identifying abnormal cervical cell changes. However, these methods can produce false-positive results just like standard Pap tests. Not all laboratories provide this testing, but liquid-based methods are becoming more widely used. These methods cost more than standard Pap testing.

Credits


Author Shannon Erstad, MBA/MPH
Editor Kathleen M. Ariss, MS
Associate Editor Denele Ivins
Associate Editor Pat Truman, MATC
Primary Medical Reviewer Joy Melnikow, MD, MPH - Family Medicine
Specialist Medical Reviewer Barbara S. Apgar, MD, MS - Family Medicine, Women's Health
Specialist Medical Reviewer Ross Berkowitz, MD - Obstetrics and Gynecology
Last Updated January 12, 2007

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Last updated: January 12, 2007
Author: Shannon Erstad, MBA/MPH
Reviewed By: Joy Melnikow, MD, MPH - Family Medicine, Ross Berkowitz, MD - Obstetrics and Gynecology
Editors: Kathleen M. Ariss, MS, Pat Truman, MATC

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