In brief: More on sleeping pills

Content provided by the Faculty of the Harvard Medical School

In brief: More on sleeping pills

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In brief

More on sleeping pills

We have received several letters asking about over-the-counter (OTC) medications like Tylenol PM that combine a pain reliever and a sleep aid. Several people said the pills helped them sleep and wanted to know if it was a good idea to keep on taking them.

The sleep-inducing ingredient in Tylenol PM is diphenhydramine, an antihistamine. People take antihistamines for hay fever or cold symptoms, but doctors have known for a long time that they also make people drowsy. Other nighttime pain relievers (Alka-Seltzer PM, Excedrin PM) contain diphenhydramine, and it’s the only active ingredient in OTC sleeping pills like Sominex and Simply Sleep. Sominex and the allergy-relief version of Benadryl have exactly the same active ingredient: 25 milligrams of diphenhydramine.

Dr. David White, director of the Sleep Disorders Program at Harvard-affiliated Brigham and Women’s Hospital, is not a fan of the antihistamines. He says they leave many people feeling groggy and tired rather than rested. And true to their anti–hay fever effects, they dry out the nose and mouth.

For people who have a hard time falling asleep, Dr. White prescribes either zolpidem (Ambien) or zaleplon (Sonata). For those who have trouble staying asleep, there are medications that stay in your system longer. The main choices have been trazodone (Desyrel), a sedating antidepressant, or one of the benzodiazepines (Ativan, Restoril, others). But trazodone doesn’t work for many people and hasn’t been well studied. The benzodiazepines cause daytime drowsiness and withdrawal symptoms if they’re taken for a long time.

In December 2004, the FDA approved a new long-acting medication, eszopiclone (Lunesta). You aren’t supposed to take the other sleeping pills for more than a few weeks. The FDA didn’t set any such time restrictions on Lunesta, so it could become the first medication approved as a sleeping pill that people can take indefinitely.

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Last updated:	August 21, 2006

Medical content reviewed by the Faculty of the Harvard Medical School. Harvard Health Publications, Copyright © 2007 by President and Fellows of Harvard College. All rights reserved. Used with permission of StayWell.

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