Holt Oram Syndrome

Content provided by National Organization for Rare Disorders

Important

It is possible that the main title of the report Holt Oram Syndrome is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

• atriodigital dysplasia
• heart-hand syndrome
• HOS1

Disorder Subdivisions

• None

General Discussion

Holt-Oram syndrome is a disorder that is characterized by abnormalities in the bones of the upper limb and a family or personal history of a congenital heart malformation or an abnormality in the electrical impulses that coordinate the muscle contraction of the heart (cardiac conduction defect). In some affected individuals, an abnormal wrist (carpal) bone is the only evidence of the disease. Seventy-five percent of those affected have a congenital heart malformation. Holt-Oram syndrome is an autosomal dominant genetic condition that is associated with an abnormality in the TBX5 gene.

Resources

American Heart Association

National Center

7272 Greenville Avenue

Dallas, TX 75231-4596

Tel: (214)373-6300

Fax: (214)373-0268

Tel: (800)242-8721

Email: inquire@heart.org

Internet: http://www.americanheart.org



Congenital Heart Anomalies, Support, Education, & Resources

2112 North Wilkins Road

Swanton, OH 43558

Tel: (419)825-5575

Fax: (419)825-2880

Email: chaser@compuserve.com

Internet: http://www.csun.edu/~hcmth011/chaser/chaser-news.html



NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse

1 AMS Circle

Bethesda, MD 20892-3675

USA

Tel: 3014954484

Fax: 3017186366

Tel: 8772264267

TDD: 3015652966

Email: NIAMSinfo@mail.nih.gov

Internet: http://www.niams.nih.gov/Health_Info



NIH/National Heart, Lung and Blood Institute Information Center

P.O. Box 30105

Bethesda, MD 20824-0105

Tel: (301)592-8573

Fax: (301)251-1223

Email: nhlbiinfo@rover.nhlbi.nih.gov



Reach: The Association for Children with Hand or Arm Deficiency

P.O. Box 54

Helston

Cornwall,, Intl TR13 8WD

United Kingdom

Tel: 0845 1306225

Fax: 0845 1300262

Email: reach@reach.org.uk

Internet: http://www.reach.org.uk



Kids With Heart National Association for Children's Heart Disorders, Inc.

1578 Careful Dr

Green Bay, WI 54304-2941

Tel: (920)498-0058

Fax: (920)498-0058

Tel: (800)538-5390

Email: kidswithheart@greenbaynet.com

Internet: http://www.kidswithheart.org



Little Hearts, Inc.

P.O. Box 171

Cromwell, CT 06416

USA

Tel: 8606350006

Fax: 8606350006

Tel: 8664354673

Email: info@littlehearts.org

Internet: http://www.littlehearts.org



Congenital Heart Information Network

1561 Clark Dr

Yardley, PA 19067

Tel: (215)493-3068

Fax: (215)493-3068

Email: mb@tchin.org

Internet: http://www.tchin.org



MUMS (Mothers United for Moral Support, Inc) National Parent-to-Parent Network

150 Custer Court

Green Bay, WI 54301-1243

USA

Tel: 9203365333

Fax: 9203390995

Tel: 8773365333

Email: mums@netnet.net

Internet: http://www.netnet.net/mums/

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:  4/28/2008

Copyright  1988, 1989, 1994, 1996, 1997, 1998, 2005 National Organization for Rare Disorders, Inc.

Last updated:	April 28, 2008